Baseline characteristic of patients presenting with lacunar stroke and cerebral small vessel disease may predict future development of depression

Autor: Melanie C. Norton, Gordana Tomic, N. Veselinović, Aleksandra M. Pavlović, Tatjana Pekmezovic, Milija Mijajlovic, Tamara Svabic Medjedovic, Z. Jovanovic, Aleksandra Radojicic, Jasna Zidverc Trajkovic, Nada Sternic
Rok vydání: 2015
Předmět:
Zdroj: International Journal of Geriatric Psychiatry. 31:58-65
ISSN: 0885-6230
DOI: 10.1002/gps.4289
Popis: Objective Cerebral small vessel disease (SVD) is associated with late-onset depression and increases the risk for depression after stroke. We aimed to investigate baseline predictors of depression after long-term follow-up in patients with SVD, initially presenting with first-ever lacunar stroke, free of depression and cognitive impairment. Methods A total of 294 patients with SVD were evaluated 3–5 years after the qualifying event. We analyzed baseline demographic data, vascular risk factors, functional status expressed as a score on modified Rankin Scale (mRS), cognitive status, presence of depression, total number of lacunar infarcts and severity of white matter hyperintensities (WMH) on MRI with Age-Related White Matter Changes scale total score (tARWMC) and Fazekas scale periventricular and deep subcortical scores. Results On follow-up, depression was registered in 117 (39.8%) SVD patients. At the baseline, patients with depression compared with non-depressed were older (64.4 vs 60.9 years; p = 0.007), had higher mRS score (2.8 ± 0.7 vs 1.5 ± 0.7; p 2 (HR 2.17, 95%CI 1.74–2.72; p
Databáze: OpenAIRE
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