Synthesis of 3-(1-aminoethyl)adamantan-1-ol by hydroxylation of 1-(1-adamantyl)ethanamine hydrochloride (rimantadine)

Autor:	Usein M. Dzhemilev, N. A. Shchadneva, Ravil I. Khusnutdinov, L. F. Khisamova
Rok vydání:	2015
Předmět:	Hydroxylation chemistry.chemical_compound Rimantadine Chemistry Hydrochloride Adamantane Organic Chemistry Pyridine Triphenyl phosphite medicine Organic chemistry medicine.drug
Zdroj:	Russian Journal of Organic Chemistry. 51:22-25
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428015010042
Popis:	A procedure has been developed for the selective synthesis of 3-(1-aminoethyl)adamantan-1-ol by hydroxylation of 1-(1-adamantyl)ethanamine hydrochloride with the system H2O-CBrCl3 in the presence of W(CO)6 activated by pyridine.
Databáze:	OpenAIRE
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