Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma

Autor:	Chengyun Zheng, Göran Holm, De Ren Huang, Anne Sundblad, Li Liu, Magnus Björkholm, Qing Yi
Rok vydání:	2001
Předmět:	Hematology Biology medicine.disease Malignancy hemic and lymphatic diseases Immunopathology Genotype Immunology Cancer research medicine Cytotoxic T cell Microsatellite Allele Multiple myeloma Monoclonal gammopathy of undetermined significance
Zdroj:	British Journal of Haematology. 112:216-218
ISSN:	0007-1048
Popis:	Multiple myeloma (MM) is a B-lineage malignancy with unknown aetiology. It has been considered that predisposing genetic factors might be implicated in the disease. In this study, the microsatellite polymorphism in the exon 3 of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene was analysed in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), together with ethnically matched healthy controls. The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and MGUS compared with matched healthy controls, indicating that the CTLA-4 microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4bb1e1ff3820fc59ba01a2ad81ea0e65 https://doi.org/10.1046/j.1365-2141.2001.02552.x Zobrazit plný text záznamu Plný text