| Autor: |
Sophie Paris, Laurent Capelle, Soledad Navarro, Yannick Marie, Marc Sanson, Khê Hoang-Xuan, Jean-Yves Delattre, Ahmed Idbaih, Jaime Gállego Pérez-Larraya, Florence Laigle-Donadey, Alain Mallet, Caroline Dehais, Karima Mokhtari |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Cancer. 120:3972-3980 |
| ISSN: |
0008-543X |
| Popis: |
BACKGROUND Circulating proteins released by tumor cells have recently been investigated as potential single surrogate biomarkers for glioblastoma multiforme (GBM). The aim of the current hypothesis-generating study was to evaluate the diagnostic and prognostic role of preoperative insulin-like growth factor-binding protein 2 (IGFBP-2), chitinase-3-like protein 1 (YKL-40), and glial fibrillary acidic protein (GFAP) plasma levels in patients with GBM, both as single markers and as a combined profile. METHODS Plasma samples from 111 patients with GBM and a subset of 40 patients with nonglial brain tumors were obtained preoperatively. Plasma from 99 healthy controls was also analyzed. IGFBP-2, YKL-40, and GFAP levels were determined using enzyme-linked immunoadsorbent assay tests. Their association with histological and radiological variables was assessed. RESULTS Circulating levels of all 3 proteins were found to be significantly higher in patients with GBM compared with healthy controls (P < .01). Only YKL-40 and GFAP were found to demonstrate significant differences between patients with GBM and nonglial brain tumors (P = .04). GFAP was undetectable ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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