Ocular Blood Flow Analysis Detects Microvascular Abnormalities in Impaired Glucose Tolerance
| Autor: | Auleen Millar, Aaron McCann, Paul Hamilton, Gary E. McVeigh, Catherine Quinn, Mark Harbinson, Christina E. Agnew, Christopher J. Lockhart |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry Retinal Blood flow medicine.disease Placebo Microcirculation Impaired glucose tolerance chemistry.chemical_compound Insulin resistance medicine.anatomical_structure Endocrinology chemistry Physiology (medical) Internal medicine medicine Cardiology Vascular resistance Cardiology and Cardiovascular Medicine business Molecular Biology Pioglitazone medicine.drug |
| Zdroj: | Microcirculation. 18:532-540 |
| ISSN: | 1073-9688 |
| DOI: | 10.1111/j.1549-8719.2011.00110.x |
| Popis: | Please cite this paper as: Quinn, Hamilton, McCann, Agnew, Millar, Lockhart, Harbinson and McVeigh (2011). Ocular Blood Flow Analysis Detects Microvascular Abnormalities in Impaired Glucose Tolerance. Microcirculation 18(7), 532–540. Abstract Objective: Waveform analysis has been used to assess vascular resistance and predict cardiovascular events. We aimed to identify microvascular abnormalities in patients with IGT using ocular waveform analysis. The effects of pioglitazone were also assessed. Methods: Forty patients with IGT and 24 controls were studied. Doppler velocity recordings were obtained from the central retinal, ophthalmic, and common carotid arteries, and sampled at 200 Hz. A discrete wavelet-based analysis method was employed to quantify waveforms. The RI was also determined. Patients with IGT were randomized to pioglitazone or placebo, and measurements were repeated after 12-week treatment. Results: In the ocular waveforms, significant differences in power spectra were observed in frequency band 4 (corresponding to frequencies between 6.25 and 12.50 Hz) between groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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