Association Between Portal Vein Thrombosis and Pouchitis in Patients with Ulcerative Colitis
| Autor: | Aslam Syed, Bo Shen, Talal Seoud, Ravi P. Kiran, Shyam Thakkar, Neil M. Carleton |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Physiology business.industry Deep vein medicine.medical_treatment Population Gastroenterology Odds ratio Pouchitis medicine.disease Ulcerative colitis Portal vein thrombosis medicine.anatomical_structure Internal medicine medicine Risk factor education business Colectomy |
| Zdroj: | Digestive Diseases and Sciences. 67:1303-1310 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-021-06969-5 |
| Popis: | Pouchitis is the most common long-term complication in patients requiring colectomy ileal pouch-anal anastomosis with medically refractory ulcerative colitis or colitis-associated neoplasia. A previous small case series suggests associated between portal vein thrombosis (PVT) and ischemic pouchitis. To evaluate the association between PVT and other demographic and clinical factors and pouchitis. We used Explorys Inc., a population-based database, to search medical records between 1999 and 2020 with SNOMED-CT code criteria for “construction of pouch” and “ileal pouchitis.” Patients with pouchitis were compared to those with previous pouch construction without pouchitis. Factors associated with pouchitis identified with univariable analysis were introduced into a multivariable model. A post hoc analysis further stratified demographical findings of the association between PVT and pouchitis. We identified 7900 patients with ileal pouchitis (7.5%) and 97,510 with pouch construction without pouchitis. In multivariate binary logistic regression, adjusted odds ratio (aOR) for the risk of pouchitis in patients with PVT was 10.78 (95% confidence interval [CI] 7.04–16.49, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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