Cocarcinogenic Interaction Between d,l -Tryptophan and 4-Aminobiphenyl or 2-Naphthylamine in Dogs 2

Autor:	William E. MacDonald, Teresa Radomski, Jack L. Radomski
Rok vydání:	1977
Předmět:	Cancer Research medicine.medical_specialty Bladder cancer Tryptophan Biology Hyperplasia medicine.disease Beagle chemistry.chemical_compound Endocrinology Oncology 4-Aminobiphenyl chemistry Cocarcinogen Internal medicine Bladder Neoplasm medicine Carcinogen
Zdroj:	JNCI: Journal of the National Cancer Institute. 58:1831-1834
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/58.6.1831
Popis:	Administration of a dietary supplement of 6 g D,L tryptophan/day for 4 1/2 years following the administration of a single dose of 50 mg 4-aminobiphenyl/kg produced a bladder tumor in 1 of 4 beagle dogs. No tumors were observed in 6 dogs given the same dose of 4-aminobiphenyl without supplemental tryptophan. In a second experiment, administration of a supplement of 6 g D,L-tryptophan/day for 3 years following the administration of 5 mg 2-naphthylamine/kg/day for 30 days produced bladder tumors in 2 of 4 dogs. No tumors or other bladder pathology was produced by treatment of 4 dogs with this dose of 2-naphthylamine alone. Dogs given D,L-tryptophan alone developed no bladder tumors, but in most dogs receiving tryptophan the "tryptophan effect", i.e., a darkly stained mucosa with white areas of focal hyperplasia, was observed. Both experiments suggest a role of D,L-tryptophan as a cocarcinogen or promotor in the induction of bladder cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b88503613a2d4f0441a3c6cadb45609 https://doi.org/10.1093/jnci/58.6.1831 Zobrazit plný text záznamu