In Vitro Effects of Oxytocin and Ionomycin on Lipid Secretion by Rat Mammary Gland. Role of the Myoepithelial Cells
| Autor: | Dermot H. Williamson, Teresa H. M. Da Costa, Vera Ilic |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Mammary gland Myoepithelial cell chemistry.chemical_element Calcium In vitro chemistry.chemical_compound medicine.anatomical_structure Endocrinology Oxytocin chemistry Internal medicine Lipid droplet Ionomycin medicine lipids (amino acids peptides and proteins) Secretion hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Intercellular Signalling in the Mammary Gland ISBN: 9781461358121 |
| Popis: | Milk is expelled from the alveolar lumen by contraction of the myoepithelial cells in response to the suckling stimuli and subsequent release of oxytocin (Robinson, 1986). The action of oxytocin is dependent on availability of external calcium (Olins and Bremel, 1984). Ionomycin is a calcium ionophore that increases protein secretion from mammary gland acini and facilitates lipid secretion by apparent leakage from lipid droplets (Turner et al., 1992). Oxytocin and ionomycin were used in an in vitro system developed to study the process of milk lipid secretion. We describe the stimulatory effects of oxytocin and ionomycin on secretion of milk constituents by their action on myoepithelial cells in the presence or absence of external calcium (Ca2+). |
| Databáze: | OpenAIRE |
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