| Autor: |
Anna-Maria Brady, P.A. Feldman, Jennifer Duguid, L. Winkelman |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
Transfusion Science. 10:287-293 |
| ISSN: |
0955-3886 |
| DOI: |
10.1016/0955-3886(89)90039-8 |
| Popis: |
Platelet-rich plasma (PRP) was apheresed from the same donors into four anticoagulant formulations favoured for preparing platelet concentrates (PC), and platelet-poor plasma (PPP) harvested by a second centrifugation. A fifth control collection was made by direct apheresis of PPP. Matched 3–4 kg pools of PPP underwent partial fractionation to determine the effects of plasma anticoagulant on factor VIII recovery and the potential thrombogenicity of prothrombin complex Although an excellent factor VIII recovery was achieved in each case, the cryoprecipitate from plasma apheresed into acid citrate dextrose formula B (ACD-B) showed evidence of incipient clotting, and the factor IX concentrate from the same plasma contained a high concentration of activated factors. It was concluded that ACD-B, in the ratio used, provides insufficient citrate for secure anticoagulation and should not be used when PPP is destined for fractionation of coagulation factor concentrates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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