ChemInform Abstract: Enantioselective NHC-Catalyzed Redox [2 + 2] Cycloadditions with Perfluoroketones: A Route to Fluorinated Oxetanes

Autor:	Alexandra M. Z. Slawin, Andrew D. Smith, Alyn Davies
Rok vydání:	2016
Předmět:	chemistry.chemical_compound chemistry Yield (chemistry) Enantioselective synthesis General Medicine Carbene Redox Combinatorial chemistry Cycloaddition Catalysis
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201619060
Popis:	The N-heterocyclic carbene (NHC) catalyzed redox formal [2+2] cycloaddition between α-aroyloxyaldehydes and perfluoroketones, followed by ring-opening in situ delivers a variety of perfluorinated β-hydroxycarbonyl compounds in good yield, and excellent diastereo- and enantioselectivity. Through a reductive work-up and subsequent cyclization, this protocol offers access to highly substituted fluorinated oxetanes in two steps and in high ee.
Databáze:	OpenAIRE
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