ChemInform Abstract: Synthesis and Anticancer Activity of Sclerophytin-Inspired Hydroisobenzofurans

Autor:	Meenakshi Upreti, Timothy C. Chambers, Kwangyul Moon, Aarti L. Joshi, Elena N. Galitovskaya, Matthias C. McIntosh, T. David Bateman
Rok vydání:	2010
Předmět:	Stereochemistry Sclerophytin A Cell culture Chemistry Growth inhibitory General Medicine Non small cell Leukemia cell line
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201016092
Popis:	Three structurally related sets of hydroisobenzofuran analogs of sclerophytin A were prepared in three or four steps from ( S )-(+)-carvone via an aldol-cycloaldol sequence. The most potent members of each set of analogs exhibited IC 50 ’s of 1–3 μM in growth inhibitory assays against KB3 cells. The NCI 60-cell line 5-dose assay for analog 6h revealed a GI 50 = 0.148 μM and LC 50 = 9.36 μM for the RPMI-8226 leukemia cell line, and a GI 50 = 0.552 μM and LC 50 = 26.8 μM for the HOP-92 non-small cell lung cancer cell line.
Databáze:	OpenAIRE
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