The generality of Constructive Neutral Evolution
| Autor: | Tyler D. P. Brunet, W. Ford Doolittle |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Spliceosome Generality Natural selection Computer science Constructive 03 medical and health sciences Philosophy Philosophy of biology Negative selection 030104 developmental biology History and Philosophy of Science Genetic drift Evolutionary biology General Agricultural and Biological Sciences Neutral theory of molecular evolution |
| Zdroj: | Biology & Philosophy. 33 |
| ISSN: | 1572-8404 0169-3867 |
| Popis: | Constructive Neutral Evolution (CNE) is an evolutionary mechanism that can explain much molecular inter-dependence and organismal complexity without assuming positive selection favoring such dependency or complexity, either directly or as a byproduct of adaptation. It differs from but complements other non-selective explanations for complexity, such as genetic drift and the Zero Force Evolutionary Law, by being ratchet-like in character. With CNE, purifying selection maintains dependencies or complexities that were neutrally evolved. Preliminary treatments use it to explain specific genetic and molecular structures or processes, such as retained gene duplications, the spliceosome, and RNA editing. Here we aim to expand the scope of such explanation beyond the molecular level, integrating CNE with Multi-Level Selection theory, and arguing that several popular higher-level selection scenarios are in fact instances of CNE. Suitably contextualized, CNE occurs at any level in the biological hierarchy at which natural selection as normally construed occurs. As examples, we focus on modularity in protein–protein interaction networks or “interactomes,” the origin of eukaryotic cells and the evolution of co-dependence in microbial communities—a variant of the “Black Queen Hypothesis” which we call the “Gray Queen Hypothesis”. |
| Databáze: | OpenAIRE |
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