Low transition temperature mixtures prompted one-pot synthesis of 5, 10 dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione derivatives
| Autor: | Ajinkya A. Patravale, Digambar R. Kumbhar, Reshma B. Patil, D. R. Chandam, Madhukar B. Deshmukh, Jai S. Ghosh, Sunetra J. Jadhav, Priyanka P. Mohire |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Barbituric acid 010405 organic chemistry One-pot synthesis Quinoline Condensation General Chemistry 010402 general chemistry 01 natural sciences Aldehyde 0104 chemical sciences Catalysis chemistry.chemical_compound Aniline chemistry Yield (chemistry) Organic chemistry |
| Zdroj: | Research on Chemical Intermediates. 43:7013-7028 |
| ISSN: | 1568-5675 0922-6168 |
| DOI: | 10.1007/s11164-017-3033-1 |
| Popis: | An efficient green protocol has been investigated for the synthesis of pyrimido[4,5-b]quinolines derivatives via one-pot three-component condensation of 4-chloro aniline, aromatic aldehyde and barbituric acid using low transition temperature mixtures as new generation and sustainable solvents. The process was accomplished with the use of greener and recyclable reaction media, simple methodology, easy workup procedures and no chromatographic purification with high yield. This new approach is expected to discover some significance in combinatorial synthesis of biologically active scaffolds. |
| Databáze: | OpenAIRE |
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