Brief Review Insulin Resistance in Chronic Renal Failure

Autor:	Lockwood Dh, McCaleb Ml, Wish Jb
Rok vydání:	1985
Předmět:	medicine.medical_specialty business.industry Insulin medicine.medical_treatment Skeletal muscle General Medicine Hindlimb medicine.disease Peripheral Endocrinology medicine.anatomical_structure Clamp Insulin resistance Forearm Internal medicine medicine business Perfusion
Zdroj:	Endocrine Research. 11:113-125
ISSN:	1532-4206 0743-5800
DOI:	10.3109/07435808509035429
Popis:	There is substantial documentation of the presence of insulin resistance in many patients with chronic renal failure (1). Circulating levels of insulin are increased and there is a delayed and reduced glucose response to the administration of insulin (2). Peripheral target tissues of uremic patients and rats are resistant to insulin action (3–6). There is reduced uptake of glucose by skeletal muscle as shown by forearm perfusion (5) and the euglycemic clamp (4) in uremic humans and by hindlimb perfusion in uremic rats (7).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b774d52061e92aefc706cf06bd9ceb1 https://doi.org/10.3109/07435808509035429 Zobrazit plný text záznamu