Synthesis and toxicity evaluation of aflatoxin P1
| Autor: | G. Buchi, S. Paglialunga, Gerald N. Wogan, D. Spitzner |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Aflatoxin
Dimethyl sulfoxide Thin layer technology industry and agriculture food and beverages Aflatoxin P1 General Medicine Median lethal dose biological factors General Biochemistry Genetics and Molecular Biology Toxicology chemistry.chemical_compound chemistry Toxicity heterocyclic compounds Food science Phosphoramide General Pharmacology Toxicology and Pharmaceutics Aflatoxins Toxicity |
| Zdroj: | Life Sciences. 13:1143-1149 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(73)90381-0 |
| Popis: | Conversion of aflatoxin B1 to its demethylated derivative, aflatoxin P1, has been achieved by treatment of the parent substance with lithium t -butylmercaptide in hexamethyl phosphoramide for 2 hours at 75°C. A preliminary toxicologic evaluation in newborn mice showed aflatoxin P1 to cause some mortality at 150 mg/kg, whereas aflatoxin B1 had an LD5 0 of 9.5 mg/kg under comparable conditions. |
| Databáze: | OpenAIRE |
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