Cardiorespiratory Responses to Inhaled Laryngeal Irritants

Autor: Giuseppe Sant'Ambrogio, Oommen P. Mathew, Frantisek Palecek, F.B. Sant'Ambrogio
Rok vydání: 1990
Předmět:
Zdroj: Inhalation Toxicology. 2:93-104
ISSN: 1091-7691
0895-8378
DOI: 10.3109/08958379009145247
Popis: Numerous protective and defensive reflexes are elicited from the upper airway, but the extent to which receptors with myelinated and nonmyelinated fibers contribute to these reflex responses is not known. In this study we compared the effects of capsaicin (CAPS), a specific C-fiber receptor stimulant, and ammonia (NH3), a nonspecific stimulant, on breathing pattern, heart rate, and blood pressure in anesthetized, spontaneously breathing rats and dogs. Nebulized CAPS and NH3 vapor were added to a constant stream of air passing through the functionally isolated upper airway In the rat both CAPS and NH3 prolonged the expiratory duration TE (p
Databáze: OpenAIRE