| Autor: |
Daniel J. Rader, Arpita Ghorai, Jing Zhang, Laura Almasy, Brielle Gehringer, Holly C. Dow, Maja Bucan, Edward S. Brodkin, Stacey Elkhatib Smidt, Sara C. Taylor, Zoe Smernoff |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Clinical and Translational Science. 4:72-72 |
| ISSN: |
2059-8661 |
| DOI: |
10.1017/cts.2020.236 |
| Popis: |
OBJECTIVES/GOALS: Autism spectrum disorder (ASD) is characterized by difficulties in communication and social interaction as well as restricted and repetitive behaviors. Sleep problems are a common concern in children with ASD that can persist into adulthood. This study aims to further explore sleep in ASD without intellectual disability (ASD w/o ID). METHODS/STUDY POPULATION: We recruited individuals of both sexes with ASD w/o ID (probands) and relatives as part of the Autism Spectrum Program of Excellence (ASPE) at the University of Pennsylvania. Actimetry data were collected via a wrist-worn tri-axial accelerometer for 21 days. Data from 212 participants were considered. We analyzed sleep data using the algorithms GGIR, ChronoSapiens, and PennZzz. The sleep traits of proband and sibling pairs were compared using paired t-test or Wilcoxon signed-rank test. We used the Social Responsiveness Scale, Second Edition (SRS-2) to assess social impairment and restricted/repetitive traits. We compared SRS-2 scores to sleep traits using partial Spearman or Pearson correlations adjusting for age (171 participants). RESULTS/ANTICIPATED RESULTS: Probands demonstrated later sleep onset (p = 0.03), decreased M10 average (10-hour period of highest activity/day; p = 0.006), decreased relative amplitude (measure of rest-activity rhythm; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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