DNA Transfection Efficiency of Antimicrobial Peptide as Revealed by Molecular Dynamics Simulation

Autor:	Namsrai Javkhlantugs, Janlav Munkhtsetseg, Chimed Ganzorig, Kazuyoshi Ueda
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Materials science Cell Cationic polymerization Peptide Transfection Molecular biology Molecular dynamics chemistry.chemical_compound medicine.anatomical_structure Membrane chemistry Amphiphile medicine Biophysics DNA
Zdroj:	MRS Proceedings. 1569:109-114
ISSN:	1946-4274 0272-9172
DOI:	10.1557/opl.2013.800
Popis:	The peptide-DNA complex was investigated by using molecular dynamics simulation to analyze the transfection efficiency of cationic amphipathic peptide. Previously, the cationic peptide, LFampinB, with positively charged amino acid residues of Lysines was used to investigate the orientation and interaction energies for entering the cell though disruption of the endosomal membrane. The same interactions were obtained for N-terminus of the LFampinB peptide with membrane and with plasmid DNA. The N-terminus of LFampinB can bind at minor groove of DNA to make complexation of the peptide with DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b696cf753ea147f819abc81c1c39e69 https://doi.org/10.1557/opl.2013.800 Zobrazit plný text záznamu Full text from SpringerLink