Effect of AY-9944 on Rat Adrenal Function1

Autor:	M. L. Givner, J. G. Rochefort, D. Dvornik
Rok vydání:	1967
Předmět:	medicine.medical_specialty Cholesterol Adrenal vein Biology Hydroxylation chemistry.chemical_compound Endocrinology chemistry Corticosterone Internal medicine medicine High doses Adrenal function Hydroxyprogesterone Cholesterol biosynthesis
Zdroj:	Endocrinology. 81:976-980
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-81-5-976
Popis:	AY-9944 [trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydroohloride], an inhibitor of cholesterol biosynthesis, was studied for its effect on adrenal corticoid synthesis. In rat adrenal homogenates AY-9944 inhibited the production of corticosterone from cholesterol, progesterone and 11-desoxy corticosterone, but did not affect its formation from 11β-hydroxyprogesterone. Adrenal homogenates from AY-9944 treated rats showed little change in their 11β-hydroxylation activity of DOC. In rats, chronic treatment with high doses of AY-9944 depressed adrenal vein corticosterone levels and impaired the capacity of the adrenals to convert circulating cholesterol-7α-3H into corticosterone. (Endocrinology 81: 976, 1967)
Databáze:	OpenAIRE
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