ACE2 gene combined with exercise training attenuates central AngII/AT1 axis function and oxidative stress in a prehypertensive rat model

Autor:	Xiu-Yun Chen, Cheng Lin, Guo-Ying Liu, Chun Pei, Gui-Qing Xu, Lie Gao, Shi-Zhong Wang, Yan-Xia Pan
Rok vydání:	2022
Předmět:	Physiology Physiology (medical)
Zdroj:	Journal of Applied Physiology. 132:1460-1467
ISSN:	1522-1601 8750-7587
DOI:	10.1152/japplphysiol.00459.2021
Popis:	Angiotensin-converting enzyme 2 (ACE2) gene in combination with exercise training (ExT) delayed the progression of hypertension via normalizing the blunted baroreflex sensitivity (BRS) and inhibiting sympathetic nerve activity (SNA). Its underlying mechanism may be related to the inhibition of AngII/AT1 axis function and central oxidative stress in the paraventricular nucleus (PVN) of prehypertensive rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b4f5b68d31a14a4394a6ca566f936fe https://doi.org/10.1152/japplphysiol.00459.2021 Zobrazit plný text záznamu