Synthesis of a new adrenal cortex imaging agent 6β-131 I-iodomethyl-19-nor cholest -5(10)-en-3β-ol (NP-59)

Autor:	Kenneth R. Hetzel, Rodney D. Ice, G P Basmadjian, William H. Beierwaltes
Rok vydání:	1975
Předmět:	Chemistry Stereochemistry Adrenal cortex Organic Chemistry General Medicine Biochemistry Imaging agent Analytical Chemistry Iodide ion medicine.anatomical_structure Nucleophile Diagnostic agent Drug Discovery medicine Radiology Nuclear Medicine and imaging Spectroscopy
Zdroj:	Journal of Labelled Compounds. 11:427-434
ISSN:	1099-1344 0022-2135
DOI:	10.1002/jlcr.2590110318
Popis:	A new adrenal cortex imaging agent. 6β-131 I-iodomethyl-19-norcholest-5(10)-en-3β-ol (NP-59)[I] was synthesized by the homallylic rearrangement of 19-iodocholesterol or directly from cholest-5-ene-3β, 19-diol-19-toluene-p-sulfonate via homoallylic rearrangement with the iodide ion as a nucleophile and subsequent exchange with Na131I. NP-59 appears to concentrate 5 times better than 19-iodocholesterol in the rat adrenal and is currently being evaluated as a possible diagnostic agent in man.
Databáze:	OpenAIRE
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