Sexual dysfunction and mood stabilizers in bipolar disorder: A review
| Autor: | M. Hernandez Abellán, R. Reina Gonzalez, C. Gómez Sánchez-Lafuente |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine Lithium (medication) media_common.quotation_subject 030232 urology & nephrology Carbamazepine Orgasm Lamotrigine medicine.disease Arousal 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Sexual dysfunction Mood medicine Bipolar disorder medicine.symptom Psychology Psychiatry media_common medicine.drug Clinical psychology |
| Zdroj: | European Psychiatry. 41:s849-s849 |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | IntroductionMood stabilizers can cause many side effects. Although many of these are well known, like thyroid and renal failure after taking lithium, sexual dysfunction side effects remains unclear.MethodsWe made a systematic computerized literature search of clinical studies using MEDLINE, The Cochrane Library and Trip for clinical studies of sexual dysfunction published up to December 2015.ResultsOnly eight relevant papers were identified. All of them studied lithium sexual dysfunction in bipolar disorder patients. Valproic acid, carbamazepine and lamotrigine were not studied in patients with bipolar disorder. Nevertheless, the three were studied in epilepsy. Clinical reports usually used Arizona Sexual Experience Scale or Psychotropic Related Sexual Dysfunction Questionnaire to measure sexual dysfunction and Brief Adherence Rating Scale to measure medication adherence. They suggest lithium could decrease desire and sexual thoughts, worse arousal and cause orgasm dysfunction. In overall, those patients with sexual dysfunction had lower level of functioning and poor compliance. Taking benzodiazepines during lithium treatment may increase the risk of sexual dysfunction even more.ConclusionThere are few studies that focus on mood stabilizers sexual dysfunction. This inevitably entails a number of limitations. First, the small sample size and, in some studies, the relative short period of follow-up may underestimate the results. Besides, practical management was not treated in any study. Actually, handling this side effect have not been well established.To conclude, this revision suggest that approximately 30% patients receiving lithium experience this side effect, and it is associated with poor medication adherence.Disclosure of interestThe authors have not supplied their declaration of competing interest. |
| Databáze: | OpenAIRE |
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