SEMINAL FLUID SENSITIVITY: ABSTINENCE IS NOT THE ANSWER
| Autor: | S. Cho, S. Hudey, T. Saco |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Infertility Vaginal discharge medicine.medical_specialty Erythema business.industry Obstetrics medicine.medical_treatment media_common.quotation_subject Immunology Diphenhydramine Semen Abstinence medicine.disease law.invention Condom law Immunology and Allergy Medicine medicine.symptom business Desensitization (medicine) medicine.drug media_common |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 121:S78 |
| ISSN: | 1081-1206 |
| DOI: | 10.1016/j.anai.2018.09.255 |
| Popis: | Introduction Seminal fluid sensitivity with localized late phase symptoms and successful intravaginal desensitization is described. Case Description A 32-year-old female presents to Allergy/Immunology clinic for seminal fluid sensitivity. Within 30 minutes of intercourse with her husband, she experiences mild vaginal pruritus. 4-5 hours later she develops clear-white vaginal discharge, severe vaginal pruritus, mucosal erythema and swelling lasting several days. She never experienced this with previous partners. Diphenhydramine improves her symptoms and condom use prevents them. She does not use spermicide or lubricants. She underwent multiple evaluations for UTIs, STIs, vaginal candidiasis and latex sensitivity, thus seminal fluid sensitivity was suspected. The patient wished to conceive, thus abstinence and condom use were not feasible. Seminal fluid skin testing was negative, but patch testing was minimally positive. Intravaginal desensitization was performed over two days utilizing 1:100, 1:10, 1:4 and full dose specimens every 45 minutes. She was then instructed to have intercourse or administer her husband's stored semen every 48-72 hours for two months with decreasing frequency thereafter. She continues to attempt to conceive without any significant symptoms. Discussion Seminal fluid hypersensitivity is a rare but important cause of infertility. Treatment is abstinence, which is unreasonable for females wishing to conceive. In vitro fertilization is an option, but it is often costly and not always successful. There have been published cases of conception after intravaginal desensitization, but none describing localized late phase reactions to seminal fluid to our knowledge. This is potentially the first reported case with successful intravaginal desensitization. |
| Databáze: | OpenAIRE |
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