Efficient syntheses of new chiral peptidomimetic macrocycles through a configurationally driven preorganization

Autor:	Miriam Bru, Santiago V. Luis, Ignacio Alfonso, M. Isabel Burguete
Rok vydání:	2005
Předmět:	Molecular model Peptidomimetic Chemistry Organic Chemistry Drug Discovery Supramolecular chemistry Ring (chemistry) Selectivity Biochemistry Combinatorial chemistry Reductive amination
Zdroj:	Tetrahedron Letters. 46:7781-7785
ISSN:	0040-4039
Popis:	A new family of 32-membered ring peptidomimetic macrocycles has been efficiently obtained in a simple one-pot two-step reductive amination reaction, from easily prepared precursors. The structural and stereochemical variables have been explored in order to rationalize the obtained selectivity. The formation of the [2A+2B] tetraimine intermediate has been explained in terms of a very favorable configurationally driven preorganization as detected by NMR, CD and molecular modeling.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b317347ca58d06adb496420d0c0071e https://doi.org/10.1016/j.tetlet.2005.09.042 Zobrazit plný text záznamu Full Text from ScienceDirect