Selective loss of resistant alleles at p15 and p16 genes in chemically-induced rat tongue cancers

Autor:	Kotaro Ogawa, Jun-ichi Tanuma, Motoo Kitano, Ichiro Semba, Hayase Shisa, Yoshikazu Hirayama, Masato Hirano
Rok vydání:	2006
Předmět:	Genetics Cancer Research Tumor suppressor gene Chromosome Cancer Biology Quantitative trait locus medicine.disease Loss of heterozygosity medicine.anatomical_structure Oncology Tongue Cancer research medicine Oral Surgery Allele Gene
Zdroj:	Oral Oncology. 42:710-717
ISSN:	1368-8375
DOI:	10.1016/j.oraloncology.2005.11.011
Popis:	Summary We previously reported that susceptibility to 4-nitroquinoline 1-oxide (4NQO)-induced tongue cancer in Dark-Agouti (DA) and Wistar/Furth (WF) rats was determined by a number of quantitative trait loci. In this article, we further scrutinized one of the quantitative trait loci at a suggestive level on rat chromosome 5. Analyzing a DNA panel of 130 (DA × WF) F2 rats treated with 4NQO showed a quantitative trait loci, containing p15 INK4B and p16 INK4A . To study the possible relevance of these genes in the development of tongue cancer, we examined 45 4NQO-induced tongue cancers in 100 (DA × WF) F1 rats for loss of heterozygosity. The incidence of loss of heterozygosity at p15 INK4B and p16 INK4A genes in large advanced tongue cancers was 37.8% and 40.0%, respectively, and the WF allele was selectively lost. Accumulation of loss of heterozygosity and methylation of the promoter regions in the tumour suppressor genes in advanced tumours suggests that they may play a role in tongue cancer progression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b29820893a7256cd98cff1fc97814fe https://doi.org/10.1016/j.oraloncology.2005.11.011 Zobrazit plný text záznamu Full Text from ScienceDirect