Mass spectrometric identification of amino acid thiohydantoins

Autor:	Kyung-Duck Song, Tateo Suzuki, Yasuhiro Itagaki, Katura Tuzimura
Rok vydání:	1976
Předmět:	chemistry.chemical_classification Chromatography Protein mass spectrometry Stereochemistry Peptide sequence tag Peptide Tripeptide Mass spectrometry Biochemistry Amino acid chemistry Molecular Medicine Peptide bond Instrumentation Peptide sequence Spectroscopy
Zdroj:	Organic Mass Spectrometry. 11:557-568
ISSN:	1096-9888 0030-493X
DOI:	10.1002/oms.1210110602
Popis:	Amino acid thiohydantoins were identified using electron impact and chemical ionization mass spectrometry. Some fragmentations of thiohydantoin ring were also identified. These results suggest that the thiohydantoin method should be useful for the stepwise peptide sequence analysis starting from the carboxyl terminus. The sequence of a model tripeptide was determined by the combination of the thiohydantoin method and mass spectrometry. In the case of peptide which contained a proline residue as their C-terminal peptide, cleavage of the peptide bond cannot be achieved.
Databáze:	OpenAIRE
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