A Study of Immunohistochemical Expression of Epidermal Growth Factor Receptor in Prostatic Lesions

Autor:	Vukanti Vijayasanti, K.R.K. Prasad, Maley Sai Kumar, P. Manimekhala
Rok vydání:	2017
Předmět:	Pathology medicine.medical_specialty biology business.industry medicine.disease Staining Lesion Basal (phylogenetics) Prostate cancer medicine.anatomical_structure Prostate biology.protein Medicine Immunohistochemistry Epidermal growth factor receptor medicine.symptom business Tyrosine kinase
Zdroj:	Indian Journal of Mednodent and Allied Sciences. 5:88
ISSN:	2347-6206 2347-6192
DOI:	10.5958/2347-6206.2017.00014.0
Popis:	Epidermal growth factor receptor (EGFR) is a 170-kDa tyrosine kinase transmembrane glycoprotein expressed in normal tissues in many organs and different types of tumours. In prostate, EGFR is expressed mainly in epithelial cells, phosphorylation of EGFR (pEGFR) which is assessed by immunohistochemical methods could be useful prognostic marker for prostate cancer cases. Tumours may affect the surrounding non-malignant tissue and pEGFR immunoreactivity in the morphologically normal prostate tissue can be used to retrieve prognostic information. In this study the membranous and cytoplasmic expression of EGFR is checked in both the basal and luminal cells. Intensity of the staining and the pattern of the staining were noted in benign, in-situ and malignant lesions and it was found that the staining intensity of the luminal cells increase with a subsequent decreased staining in the basal layer as the lesion progress towards malignancy. Subsequently the staining intensity and patterns were correlated with the Gleason grade for triaging of the cases into different prognostic groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b1b7ea6cdc0541e6c16e362282ef607 https://doi.org/10.5958/2347-6206.2017.00014.0 Zobrazit plný text záznamu