Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs

Autor:	Nina Polakovicova, Antonia Vania Adji, Laura J Myhill, Andrew R Williams
Rok vydání:	2023
Předmět:	Infectious Diseases Immunology and Allergy
Zdroj:	The Journal of Infectious Diseases.
ISSN:	1537-6613 0022-1899
Popis:	Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric and extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection with 2 evolutionary divergent enteric pathogens, the bacterium Citrobacter rodentium and the helminth Heligmosomoides polygyrus. Coinfection caused reduced weight gain and promoted type 1–biased inflammation. In contrast, T. muris–infected mice were more resistant to migrating Ascaris suum larvae in the lungs. Our results highlight the divergent nature of pathogen interactions and suggest that whipworm infection is a risk factor for coinfections with other pathogens within the gastrointestinal tract.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4b14cc57ff13a7d08098144dabcd6c61 https://doi.org/10.1093/infdis/jiad063 Zobrazit plný text záznamu