ChemInform Abstract: Synthesis and Structure-Activity Relationships of Thiotetronic Acid Analogues of Thiolactomycin
| Autor: | Ziegler Carl B, John P. Dirlam, Thomas N. O'Connell, Barbara J. Kamicker, David M. George, Sheryl L. Santoro, Subas M. Sakya, Melani Suarez-Contreras, Shigeru F. Hayashi |
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| Rok vydání: | 2010 |
| Předmět: |
Natural product
biology medicine.drug_class animal diseases Antibiotics General Medicine biology.organism_classification medicine.disease_cause Microbiology chemistry.chemical_compound chemistry Staphylococcus aureus otorhinolaryngologic diseases medicine Structure–activity relationship Pasteurella multocida Thiotetronic acid |
| Zdroj: | ChemInform. 33 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200204237 |
| Popis: | 3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycin against Staphylococcus aureus and comparable activity against Pasteurella multocida. Several semisynthetically modified analogues of thiolactomycin showed no improvement in activity over thiolactomycin. |
| Databáze: | OpenAIRE |
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