PVN SK channel blockade alters sympathetic nerve bursting pattern in angiotensin II-infused rats
| Autor: | Jenna Disser, Qing-Hui Chen, Robert Larson |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Physiology. 38 |
| ISSN: | 1548-9221 1548-9213 |
| Popis: | Sympathetic nerve activity (SNA) is known to demonstrate rhythmic activity that is synchronized with the respiratory and the cardiac cycles. These oscillations arise through integration of signals from lung inflation afferents, baroreceptor afferents, and respiratory neurons in the brainstem that influence presympathetic neurons in the rostral ventrolateral medulla (RVLM). The hypothalamic paraventricular nucleus (PVN) is a prominent regulatory center for sympathetic nerve activity (SNA) and PVN neurons have axon projections to the RVLM. Blockade of small conductance calcium-activated potassium (SK) channels in the PVN significantly increases splanchnic and renal SNA and dysfunction of SK channels contributes to the pathogenesis of hypertension. The aim of this study was to determine the influence of chronic AngII infusion on SNA firing patterns at rest and following PVN SK channel blockade with apamin. All experiments were performed in ventilated, anesthetized (urethane 800mg/kg & α-chloralose 80mg/kg) male Sprague-Dawley control (Ctrl; n=5) rats, or rats infused with AngII (150 ng·kg−1·min−1) for 2 weeks (n=4). Bilateral PVN microinjection of the SK channel blocker apamin (12.5pmol, 50μL) significantly (p Funding: Michigan Technological University (Larson); NIH 1R15HL145655(Chen) This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|