SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?
| Autor: | Li Rui Sun, Si Yu Li, Wei Zhou, Hong-Mei Zhang, Qiu Shi Guo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Intravasation Wnt signaling pathway Cancer Biology medicine.disease medicine.disease_cause Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research medicine Epithelial–mesenchymal transition Carcinogenesis PI3K/AKT/mTOR pathway |
| Zdroj: | Cancer Management and Research. 12:3561-3569 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s249754 |
| Popis: | Background Cancer metastasis is the main obstacle to increasing the lifespan of cancer patients. Epithelial-to-mesenchymal transition (EMT) plays a significant role in oncogenic processes, including tumor invasion, intravasation, and micrometastasis formation, and is especially critical for cancer invasion and metastasis. The extracellular matrix (ECM) plays a crucial role in the occurrence of EMT corresponding to the change in adhesion between cells and matrices. Conclusion SPOCK1 is a critical regulator of the ECM and mediates EMT in cancer cells. This suggests an important role for SPOCK1 in tumorigenesis, migration and invasion. SPOCK1 is a critical regulator of some processes involved in cancer progression, including cancer cell proliferation, apoptosis and migration. Herein, the functions of SPOCK1 in cancer progression are expounded, revealing the association between SPOCK1 and EMT in cancer metastasis. SPOCK1 is a positive downstream regulator of transforming growth factor-β, and SPOCK1-mediated EMT regulates invasion and metastasis through the Wnt/β-catenin pathway and PI3K/Akt signaling pathway. It is of significance that SPOCK1 may be an attractive prognostic biomarker and therapeutic target in cancer treatment. |
| Databáze: | OpenAIRE |
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