ICAM1 gene polymorphism in late-onset Alzheimer’s disease

Autor: Juraj Javor, Barbora Vašečková, Veronika Režnáková, Maria Kralova, Ivana Shawkatová, Ján Pečeňák, Peter Filipcik, Gabriel Minarik, Vladimíra Ďurmanová, Zuzana Párnická
Rok vydání: 2019
Předmět:
Zdroj: Biologia. 74:1531-1538
ISSN: 1336-9563
0006-3088
DOI: 10.2478/s11756-019-00295-y
Popis: Intercellular Adhesion Molecule-1 (ICAM-1) is a cell surface glycoprotein with possible involvement in the pathogenesis of Alzheimer’s disease (AD). Therefore, sequence variations in the ICAM1 gene affecting ICAM-1 structure or expression level may play a role in the genetic susceptibility to AD. The aim of the current study was to examine the potential associations of two functional ICAM1 gene polymorphisms rs1799969 and rs5498 with the risk of AD development. 123 unrelated AD subjects (mean age 79.5 ± 6.0 years) and 265 controls (mean age 73.2 ± 9.4 years) of Slovak origin were involved in the study. Genotyping of ICAM1 rs1799969 and rs5498 SNPs was performed by PCR-RFLP. The APOEe4 allele carriage status as the major known risk factor for AD development was determined by direct sequencing. Possible association of ICAM1 gene variants with AD risk was evaluated by logistic regression analysis. Our study revealed no statistically significant association of ICAM1 rs1799969 and rs5498 polymorphisms with risk of AD development. Stratification of study groups according to their APOEe4 carriage status showed only moderate changes. Analysis of influence of ICAM1 genotypes on clinical findings such as age at disease onset and degree of cognitive impairment in AD patients showed modest, but significant association of the rs5498 AA genotype with higher severity of cognitive decline. In conclusion, our findings do not support the role of ICAM1 polymorphism as an independent genetic factor for Alzheimer’s disease susceptibility.
Databáze: OpenAIRE
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