| Autor: |
Frank Yocca, Carlos M. Villalon, Andrew Sleight, Trevor Sharp, Pramod R. Saxena, Bryan Roth, John A. Peters, Stephen J. Peroutka, John Neumaier, Ewan Mylecharane, Derek N. Middlemiss, Graeme R. Martin, Luc Maroteaux, Klaus Peter Latté, Patrick P. A. Humphrey, Daniel Hoyer, Rebecca Hills, Katharine Herrick-Davis, Julie Hensler, René Hen, Paul R. Hartig, Michel Hamon, Mark Hamblin, Manfred Göthert, Richard M. Eglen, Aline Dumuis, Marlene L. Cohen, Amy Butler, Theresa Branchek, Joel Bockaert, Gordon Baxter, Nicholas M. Barnes, Rodrigo Andrade |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
IUPHAR/BPS Guide to Pharmacology CITE. 2023 |
| ISSN: |
2633-1020 |
| DOI: |
10.2218/gtopdb/f1/2023.1 |
| Popis: |
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 491]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [471, 387]). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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