Chromium picolinate supplementation improves cardiac metabolism, but not myosin isoenzyme distribution in the diabetic heart
| Autor: | K. L. Guidry, g. S. Morris, Maren Hegsted, D. L. Hasten |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Hexokinase Nutrition and Dietetics Endocrinology Diabetes and Metabolism Clinical Biochemistry Metabolism Biology Streptozotocin medicine.disease Biochemistry chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus Myosin medicine biology.protein Glucose homeostasis Citrate synthase Myofibril Molecular Biology medicine.drug |
| Zdroj: | The Journal of Nutritional Biochemistry. 7:617-622 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/s0955-2863(96)00121-0 |
| Popis: | Because chromium (Cr) containing compounds are thought to improve glucose homeostasis, we hypothesized that chromium picolinate (CrP) could partially reverse diabetes-induced damage to cardiac tissue. Young, adult female rats were fed either a basal diet (CONT), a basal diet containing no CrP and made diabetic (DIAB-CONT) or a basal diet containing 600 ng/g of CrP (3 times the suggested daily chromium intake) and made diabetic (DIAB-CrP). Diabetes was induced by a single streptozotocin injection, 55 mg/kg i.p. After 8 weeks animals were sacrificed, hearts removed, and spectrophotometrically analyzed for citrate synthase (CS), hexokinase (HK), and beta hydroxyacyl CoA dehydrogenase activity (HOAD). Cardiac myosin isoenzymes were separated from crude myofibril extracts by PAGE electrophoresis. Diabetes did not alter CS activity relative to the CONT group, but did significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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