Synthesis of Enantiomerically Pure β- and γ-Amino Acids from Aspartic and Glutamic Acid Derivatives

Autor:	M. Bonato, Ph. Viallefont, M. Follet, D. Razafindramboa, M. L. Roumestant, A. El Marini
Rok vydání:	1992
Předmět:	chemistry.chemical_classification Chemistry Yield (chemistry) Organic Chemistry Leaving group Organic chemistry Glutamic Acid Derivatives Catalysis Amino acid
Zdroj:	Synthesis. 1992:1104-1108
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-1992-26315
Popis:	An efficient synthesis of enantiomerically pure β- and γ-amino acids starting from commercially available aspartic and glutamic acid derivatives is described. The acid function, α to the amino group, is first transformed to a good leaving group and the product reacted with organocuprates to yield β- and γ-amino esters. After deprotection β- and γ-amino acids are obtained in good overall yields
Databáze:	OpenAIRE
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