MR imaging of diffusion of3He gas in healthy and diseased lungs

Autor:	Dmitriy A. Yablonskiy, Jason C. Leawoods, Mark S. Conradi, Vikram D. Kodibagkar, David S. Gierada, Joel D. Cooper, Brian Saam, Stephen S. Lefrak
Rok vydání:	2000
Předmět:	Lung Inhalation Chemistry business.industry Diffusion Hyperpolarized Helium 3 respiratory system Thermal diffusivity respiratory tract diseases medicine.anatomical_structure Coronal plane medicine Radiology Nuclear Medicine and imaging Lung volumes Spin density Nuclear medicine business
Zdroj:	Magnetic Resonance in Medicine. 44:174-179
ISSN:	1522-2594 0740-3194
Popis:	Hyperpolarized (3)He gas MRI was used to form maps of the effective diffusivity of gas in human lungs. Images of diffusion as well as spin density are presented from a study of 11 healthy volunteers and 5 patients with severe emphysema. The effective rate of diffusion, D(e), of the gas is reduced by the alveolar walls; tissue destruction in emphysema is hypothesized to result in larger D(e). Indeed, the mean value of D(e) in the emphysematous lungs is found here to be about 2.5 times that of healthy lungs, although still smaller than the unrestricted diffusivity of (3)He in free air. Histograms of D(e) values across coronal slices are presented. The results are discussed in terms of spatial variations, variations among individuals, healthy and diseased, and variations due to changes in lung volume. Magn Reson Med 44:174-179, 2000.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4aec16011fa937e8d984284e03236454 https://doi.org/10.1002/1522-2594(200008)44:2<174::aid-mrm2>3.0.co Zobrazit plný text záznamu Plný text