Synthesis and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan as gastrosparing NSAIDS
| Autor: | Arun Rasheed, Y. Prasanna Raju, K. P. Mansoor, Nija Balan, G. Lathika, A. K. Azeem |
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| Rok vydání: | 2015 |
| Předmět: |
Chromatography
010405 organic chemistry Vanillin Organic Chemistry Tryptophan Glutathione Prodrug Ulcer index 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Biochemistry Lipophilicity medicine Aceclofenac General Pharmacology Toxicology and Pharmaceutics Quercetin medicine.drug |
| Zdroj: | Medicinal Chemistry Research. 25:70-82 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-015-1469-7 |
| Popis: | Synthesis, physicochemical characterization and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan have been attempted to develop novel gastrosparing NSAIDs, devoid of ulcerogenic side effects. The structures of synthesized prodrugs were confirmed by IR, 1H NMR, 13C NMR and mass spectroscopy. The hydrolysis kinetics studies were performed in simulated gastric fluid, simulated intestinal fluid and rat fecal matter. Its anti-inflammatory and ulcer index were analyzed along with estimation of biochemical parameters (GWM and Hexosamine), oxidative parameters (LPO, GSH, CAT, and SOD) and protein estimation. The results indicated that the synthesized prodrugs are chemically stable, biolabile and possesses optimum lipophilicity. They also exhibited retention of anti-inflammatory activity with reduced ulcerogenicity. The study showed that the mutual prodrugs are better in action compared to the parent drug and have fewer gastrointestinal side effects. |
| Databáze: | OpenAIRE |
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