Effect of exchange transfusion on the elimination of digoxin in neonates
| Autor: | G. Wettrell, K. E. Andersson, L. Nyberg |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Pharmacology
Digoxin Chemistry medicine.medical_treatment digestive oral and skin physiology Pharmacology toxicology Exchange transfusion General Medicine carbohydrates (lipids) Pharmacokinetics Anesthesia Plasma concentration polycyclic compounds medicine Pharmacology (medical) Open model cardiovascular diseases Tissue distribution medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 10:25-29 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00561545 |
| Popis: | By means of an86Rb-uptake inhibition assay, changes in the plasma concentration of digoxin and the amount of the glycoside removed during exchange transfusion have been studied in two newborns. For comparison, the exchange procedure was simulated by a computer on the basis of a two-compartment open model and available pharmacokinetic constants. A rapid decrease in plasma digoxin concentration during exchange transfusion was found when the glycoside was administered intravenously or intramuscularly within 60 min before the procedure. The amount of digoxin removed by the exchange was less than 6 per cent of the given dose. Computer simulation of the procedure also showed removal of only a minor amount of digoxin. It is concluded that the decrease in plasma concentration and the removal of only a small amount of glycoside by the exchange transfusion can be attributed mainly to extensive tissue distribution of digoxin. The results imply that replacement of digoxin after an exchange transfusion seems unnecessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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