Synthetic approach to seco-tetracenomycin natural products saccharothrixone A–C

Autor:	Kamala Prasad Vasikarla, Harikrishna Sanapa, Beeraiah Baire, Bhavani Shankar Chinta
Rok vydání:	2018
Předmět:	Abstract design 010405 organic chemistry Chemistry Organic Chemistry Drug Discovery 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences
Zdroj:	Tetrahedron Letters. 59:1970-1973
ISSN:	0040-4039
Popis:	Design and development of first synthetic approach to the functionalized tetracyclic framework of structurally novel seco-tetracenomycin natural products saccharothrixones A–C has been reported. A thermal dehydro Diels-Alder reaction of an arenyne-alkyne unit has been utilized as the key synthetic step. This strategy has been extended for the generation of a small library of diversely functionalized tetracyclic systems of seco-tetracenomycins. An approach for the synthesis of poly-hydroxyl tetracyclic system has also been described. This report represents the first synthetic approach to the tetracenomycin natural products saccharothrixones A–C.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4ad876f45aed358f40ab1a5b488cd633 https://doi.org/10.1016/j.tetlet.2018.04.031 Zobrazit plný text záznamu Full Text from ScienceDirect