Vitamin E boosted the protective potential of Aloe vera in CCl4-treated rats
| Autor: | Muhammaed Shiraz Yasin, Iram Murtaza, Hira Anwar, Wasim Shehzad, Ihsan Ullah, Rida Fatima, Tahir Ali |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
biology
business.industry medicine.medical_treatment Vitamin E CCL4 Histology Cell Biology Plant Science Pharmacology biology.organism_classification Body weight Biochemistry Aloe vera hemic and lymphatic diseases Toxicity Genetics medicine Abnormal Liver Function Test Animal Science and Zoology business Molecular Biology Adjuvant Ecology Evolution Behavior and Systematics |
| Zdroj: | Biologia. 77:269-276 |
| ISSN: | 1336-9563 0006-3088 |
| DOI: | 10.1007/s11756-021-00932-5 |
| Popis: | Aloe vera is a medicinal plant widely used for biomedical, pharmaceutical, and cosmetic applications. Oodles studies are going on to evaluate the protective role of Aloe vera while treating it along with different adjuvants compounds/drugs or plants. Therefore, here we aimed to illuminate the combined effect of Aloe vera and Vitamin E against CCl4-induced toxicity. Rats treated with CCl4 displayed reduced body weight, impaired peripheral and cellular (serum/tissues) redox/defense system, abnormal liver function tests, and abnormal histology (liver/Brain); the effect was rescued by the Aloe vera (ethanolic extract) treatment. However, the adjuvant treatment of Vitamin E significantly enhanced the anti-toxic impact of Aloe vera by attenuating free radical production, boosting antioxidants enzyme activities, and improving liver and brain tissues histology. Our findings suggest that Vitamin E enhances the beneficial effects of Aloe vera and could be used as an adjuvant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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