Long-Term Metabolic Consequences of Intrauterine Growth Restriction
| Autor: | Jae Hyun Kim, Kyoung Eun Joung, Jieun Lee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fetus
business.industry Intrauterine growth restriction Type 2 diabetes medicine.disease Bioinformatics Obesity Coronary artery disease 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine General Earth and Planetary Sciences Microbiome Epigenetics Endothelial dysfunction business 030217 neurology & neurosurgery General Environmental Science |
| Zdroj: | Current Pediatrics Reports. 8:45-55 |
| ISSN: | 2167-4841 |
| DOI: | 10.1007/s40124-020-00212-x |
| Popis: | To summarize recent findings on the associations of intrauterine growth restriction (IUGR) and long-term metabolic consequences such as obesity, type 2 diabetes (T2D), and cardiovascular diseases and the underlying mechanisms. Recent evidence suggests that metabolic diseases such as obesity, T2D, hypertension, and coronary artery disease are related to developmental programming in fetal period and early childhood. Rapid postnatal catch-up growth is also an important factor that contributes to the development of these long-term metabolic complications. The underlying mechanisms include oxidative stress, changes in hormonal milieu, vascular endothelial dysfunction, epigenetic regulation, and the potential alteration of microbiome. Fetal and early life environment is an important determinant of long-term cardiometabolic risks. Children with IUGR need close follow-up for early detection of these complications. |
| Databáze: | OpenAIRE |
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