Prospective Study to Assess the Optimal Blood Concentration of Tacrolimus in Japanese Patients with Rheumatoid Arthritis
| Autor: | Toshihiko Ishida, Hiroaki Dobashi, Kentaro Susaki, Yoshiharu Takiguchi, Katuharu Kittaka, Hitoshi Kawazoe, Hitoshi Houchi, Noriyasu Fukuoka, Michiaki Tokuda, Tomohiro Kameda |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Health Toxicology and Mutagenesis chemical and pharmacologic phenomena Pharmacology Toxicology medicine.disease Gastroenterology Tacrolimus surgical procedures operative Blood concentration Therapeutic drug monitoring Internal medicine Rheumatoid arthritis medicine Methotrexate Adverse effect Prospective cohort study business Rheumatism medicine.drug |
| Zdroj: | Journal of Health Science. 55:435-440 |
| ISSN: | 1347-5207 1344-9702 |
| Popis: | We performed a prospective study to assess the optimal blood concentration of tacrolimus in Japanese patients with rheumatoid arthritis (RA). The dose of tacrolimus (1-3mg/day) was administered orally once daily after the evening meal, and the blood concentration of tacrolimus 12 hr after administration was quantified. A total of 23 patients were enrolled. Clinical efficacy was assessed using the Disease Activity Score in 28 joints and European League Against Rheumatism (EULAR) response criteria at each outpatient visit during months 1-6. The ratio of patients who showed a moderate or good response was 47.8% (11/23). The mean blood concentrations of tacrolimus in EULAR responders and EULAR non-responders were 5.5±3.6 (mean±S.D.) and 3.1±1.9 ng/ml, respectively (p=0.069). Interestingly, although tacrolimus had lower mean blood concentrations ( |
| Databáze: | OpenAIRE |
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