Ca substitution of Sr in Sr-doped TiO2 nanotube film on Ti surface for enhanced osteogenic activity
| Autor: | Yanni Zhang, Yong Han, Kun Wang, Kai Dong, Yang Song, Enping Feng, Tingli Lu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Anodizing Tio2 nanotube Doping General Physics and Astronomy chemistry.chemical_element Hydrothermal treatment 02 engineering and technology Surfaces and Interfaces General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Mineralization (biology) Osseointegration 0104 chemical sciences Surfaces Coatings and Films chemistry Chemical engineering Implant 0210 nano-technology Titanium |
| Zdroj: | Applied Surface Science. 528:147055 |
| ISSN: | 0169-4332 |
| DOI: | 10.1016/j.apsusc.2020.147055 |
| Popis: | The intrinsic bioinertness of titanium (Ti) as an endosseous implant is still a grand challenge to achieve faster and stable implant osseointegration. A multitude of TiO2 nanotubes loaded with Sr have been developed to improve the biological performance of Ti implants, which, however, remained limited. In this study, a Sr&Ca co-doped TiO2 nanotube film (M-SrCaNT) was fabricated using a modified anodization, following by hydrothermal treatment. Results showed that half amount of Sr in Sr-doped TiO2 nanotubes (M-SrNT) could be substituted by Ca to generate M-SrCaNT, without changing the nanotubular structure. Interestingly, M-SrNT and M-SrCaNT revealed similar micro/nano-topographic surface characteristics. The production of osteogenic signals by TiO2 nanotubes (M-NT) was obviously limited as compared with Ti, which could be could be compensated by M-SrNT with superior surface micro/nano-topography and bioactive element Sr. Furthermore, as compared with M-SrNT, M-SrCaNT with the co-presence of Sr&Ca exhibited much more efficient in enhancing the attachment, proliferation and osteogenic activities (gene expressions, extracellular matrix synthesis and mineralization) of MC3T3-E1 cells. This study provided an outstanding biomimetic surface constructed by co-incorporating Sr&Ca into TiO2 nanotubular structure on Ti implant. It represented a promising approach for rapid formation of strong and long-lasting bond between implant-bone interface. |
| Databáze: | OpenAIRE |
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