Molecular Binding and Assembly Behavior of β-Cyclodextrin with Piperazine and 1,4-Dioxane in Aqueous Solution and Solid State
| Autor: | Yu Liu, Zi-Xin Yang, Fei Ding, Yong Chen, Ying-Ming Zhang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Cyclodextrin General Chemistry Nuclear magnetic resonance spectroscopy 1 4-Dioxane Crystal structure Condensed Matter Physics chemistry.chemical_compound Crystallography Piperazine chemistry Covalent bond Moiety Organic chemistry General Materials Science |
| Zdroj: | Crystal Growth & Design. 12:1370-1377 |
| ISSN: | 1528-7505 1528-7483 |
| DOI: | 10.1021/cg201446x |
| Popis: | The molecular binding behaviors of mono-[6-deoxy-6-(1-piperazinyl)]-β-cyclodextrin (1), piperazine/β-cyclodextrin complex (2), and dioxane/β-cyclodextrin complex (3) were systematically investigated by NMR spectroscopy, mass spectrometry, dynamic light scattering, viscosity measurements, microcalorimetry, crystallography, and electron microscopic observations, displaying that the self-aggregation of piperazine-modified cyclodextrin 1 in both aqueous solution and the solid state produced a head-to-tail polymeric helical structure. In contrast, the cyclodextrin units in piperazine/β-cyclodextrin complex 2 were located in a staggered pattern, which was strikingly distinctive from the reported results by slow solvent evaporation method. Despite the fact that piperazinyl moiety was introduced by covalent and noncovalent chemical bonds in compound 1 and complex 2, respectively, these two superstructures have the same crystal systems and space groups, which was clearly distinguished from the crystal structure of... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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