Paroxysmal cold hemoglobinuria due to an IgA Donath-Landsteiner antibody
| Autor: | Nicholas S Whipple, Winfred C. Wang, Kerri Nottage, JoAnn M Moulds, Dawn A B Moreau, Jane S. Hankins |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Hemolytic anemia
biology business.industry Clinical course Autoantibody Hematology medicine.disease Donath-Landsteiner antibody Blood cancer Oncology Pediatrics Perinatology and Child Health Immunology biology.protein Medicine Paroxysmal cold hemoglobinuria Antibody Autoimmune hemolytic anemia business |
| Zdroj: | Pediatric Blood & Cancer. 62:2044-2046 |
| ISSN: | 1545-5009 |
| Popis: | Paroxysmal cold hemoglobinuria (PCH) is an autoimmune hemolytic anemia (AIHA) characterized by the presence of a Donath–Landsteiner (D-L) antibody. PCH occurs most commonly in young children and is associated with acute, often self-limited hemolytic anemia. The D-L antibody is classically a biphasic IgG anti-P autoantibody identified by the D-L test. Rare case reports confirm the existence of IgM D-L antibodies. We report the case of a 2-year-old male diagnosed with acute AIHA and found to have PCH caused by an IgA D-L antibody. The clinical course and treatment of this condition, which has not been reported previously, are described. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text