Fluctuations in order–disorder transitions in the DNA–ligand complexes with various binding mechanisms
| Autor: | Ara P. Antonyan, Y. Sh. Mamasakhlisov, P. H. Vardevanyan, Sh. A. Tonoyan, A. Y. Mamasakhlisov |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Ligand General Physics and Astronomy Cooperativity Atmospheric temperature range 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Order (biology) chemistry 0103 physical sciences Biophysics Denaturation (biochemistry) Heat denaturation 010306 general physics DNA |
| Zdroj: | Journal of Contemporary Physics (Armenian Academy of Sciences). 52:173-179 |
| ISSN: | 1934-9378 1068-3372 |
| Popis: | The melting of the DNA–ligand complex is considered theoretically for the ligands binding with the DNA by two mechanisms. The obtained results describe the experimentally observed behavior of such quantities as the denaturation degree and the correlation length depending on the concentration of ligands. It is shown that the heat and cold denaturations of the DNA–ligand complexes exhibit the same cooperativity, as the heat denaturation of the pure DNA. At the same time, the temperature range of the cold denaturation is essentially narrower than the interval for the heat denaturation of the pure DNA and the DNA–ligand complexes. |
| Databáze: | OpenAIRE |
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