Patterns and frequencies of acquired and constitutional uniparental isodisomies in pediatric and adult B-cell precursor acute lymphoblastic leukemia
| Autor: | Kristina Lundin, Andrea Biloglav, Linda Olsson, Setareh Safavi, Kajsa Paulsson, Bertil Johansson |
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| Rok vydání: | 2016 |
| Předmět: |
Uniparental Isodisomies
Oncology Genetics Cancer Research medicine.medical_specialty Single-nucleotide polymorphism Biology Genetic analysis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure CDKN2A 030220 oncology & carcinogenesis Internal medicine medicine SNP Hyperdiploidy B cell 030215 immunology SNP array |
| Zdroj: | Genes, Chromosomes and Cancer. 55:472-479 |
| ISSN: | 1045-2257 |
| DOI: | 10.1002/gcc.22349 |
| Popis: | Single nucleotide polymorphism (SNP) arrays are increasingly being used in clinical routine for genetic analysis of pediatric B-cell precursor acute lymphoblastic leukemias (BCP ALL). Because constitutional DNA is not readily available as a control at the time of diagnosis, it is important to be able to distinguish between acquired and constitutional aberrations in a diagnostic setting. In the present study we focused on uniparental isodisomies (UPIDs). SNP array analyses of 143 pediatric and 38 adult B-cell precursor acute lymphoblastic leukemias and matched remission samples revealed acquired whole chromosome or segmental UPIDs (wUPIDs, sUPIDs) in 32 cases (18%), without any age- or gender-related frequency differences. Acquired sUPIDs were larger than the constitutional ones (mean 35.3 Mb vs. 10.7 Mb; P |
| Databáze: | OpenAIRE |
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