The Effect of Adding Chondroadherin to an Injectable Ceramic Bone Substitute on Bone Ingrowth

Autor:	L. Lidgren, D. Heinegard, J.-S. Wang, H. E. Ozturk
Rok vydání:	2010
Předmět:	Scaffold Materials science Bone substitute Ceramic engineering Fibroin Nanotechnology General Medicine Bone tissue engineering Chondroadherin Bone ingrowth visual_art visual_art.visual_art_medium Ceramic Biomedical engineering
Zdroj:	Bioceramics Development and Applications. 1:1-4
ISSN:	2090-5033 2090-5025
DOI:	10.4303/bda/d101105
Popis:	Objective. The aim of the present study is to prepare a 3D porous silk fibroin scaffold with a hierachical structure that can meet the demands for bone tissue engineering. Materials and Methods. 3D fibroin scaffold was prepared by the methods of partial dissolution in acid solution and freeze drying fibroin solution. Results. The nets were composed of a mesh of randomly oriented fibers that ranged between 10 ?m and 30 ?m in diameter. Branchpoints and three dimensional open spaces were distributed throughout the structure with an average pore size of about 177.9 ± 40.0 ?m. Conclusion. With the methods of non-woven silk fibroin net preparation and frozen-dried technics, it is possible to prepare a 3D porous silk fibroin scaffold with hierachical fine structure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4abc4b6bcd0d209c799d0c0aee50f8d3 https://doi.org/10.4303/bda/d101105 Zobrazit plný text záznamu