Changes in Motor Asymmetry of the Goldfish Related to Adaptation to Vestibular Stimulation and Applications of Beta-Amyloid on Mauthner Cells
| Autor: | N. R. Tiras, G. A. Alilova, N. A. Pen’kova, Ye. N. Besgina, D. A. Moshkov |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Neurophysiology. 47:115-127 |
| ISSN: | 1573-9007 0090-2977 |
| DOI: | 10.1007/s11062-015-9507-0 |
| Popis: | We examined effects resulting from application of aggregated beta-amyloid on Mauthner neurons (MNs) of ambidextral goldfishes and long-lasting rotatory stimulation on lateral motor behavior of such fishes; these individuals were preliminarily adapted to repetitive rotatory stimulation. Using 3D histological reconstruction of the above cells, we measured the volumes of the right and left MNs and examined the ultrastructure of specialized synaptic compartments in excitatory synapses localized on the surface of the soma, lateral dendrite, and ventral dendrite of these cells. In the course of the experiments, control fishes remain ambidextrals, and the mean volumes of the right and left MNs in these individuals were close to each other. In a fish of this group, dimensions of the active zones (AZs) of chemical synapses localized on the lateral dendrite were considerably greater in the right neuron, while those in synapses on the lateral dendrite were smaller in the left neuron. Experimental fishes subjected to the above-mentioned procedures demonstrated clearly expressed motor lateralization; the mean volumes of their right and left MNs were, however, practically equal to each other. Ultrastructural analysis of peculiarities of MNs of such a fish showed that dimensions of the AZs in chemical synapses on the soma and lateral dendrite of the left MN, which became much less active functionally, significantly exceeded the analogous indices in synapses of the same localization on the right, more active, MN. In mixed synapses, the mean dimensions of gap junctions in control and experimental individuals were similar to each other independently of localization of such synapses. Interrelations between functional asymmetry of MNs manifested in lateralization of motor behavior of the fishes and dimensions of synaptic structures on these cells are discussed. |
| Databáze: | OpenAIRE |
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