Les rémissions induites à la phase précoce du diabète insulinodépendant: existe-t-il des facteurs prédictifs?
| Autor: | R. Maréchaud, F. Rossi, Abadie Jc, Gouet D, Y. Sudre |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry C-peptide Insulin medicine.medical_treatment Gastroenterology Peptide hormone medicine.disease Artificial pancreas Metformin Glibenclamide chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus Internal Medicine medicine business medicine.drug |
| Zdroj: | La Revue de Médecine Interne. 5:206-211 |
| ISSN: | 0248-8663 |
| DOI: | 10.1016/s0248-8663(84)80055-7 |
| Popis: | The induction of a remission has been attempted in 28 patients with insulin-dependent diabetes of less than 3 months' duration by strictly normalizing glycemia either with a period of external artificial pancreas followed by continuous subcutaneous insulin infusion (22 patients) or with continuous subcutaneous insulin infusion alone (6 patients). HLA A, B and DR antigens were determined in every patient. Residual beta-cell function was evaluated by measuring C peptide and the ratio of C peptide to glycemia, and by testing the response to a glucagon stimulation before initiating and after withdrawing insulin treatment. Oral treatment with 15 mg glibenclamide and 840 mg metformin daily was administered when insulin had been stopped. A remission was obtained in 17 of the 28 cases. The likelihood of a remission was greater if: (1) the patient was older (mean age was 25.6 years in case of success and 16.6 Years in case of failure); (2) initial daily needs for insulin were smaller (0.88 v. 1.23 U/kg); and (3) stimulated secretion of C peptide was larger (0.22 v. 0.11 mmol/l). |
| Databáze: | OpenAIRE |
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